Tissue Bioengineering Laboratory

PEER REVIEWED JOURNAL PAPERS

2016
1. Bo Wang, Sourav S. Patnaik, Bryn Brazile, J. Ryan Butler, Andrew Claude, Ge Zhang, Jianjun Guan, Yi Hong, and Jun Liao. Establishing Early Functional Perfusion and Structure in Tissue Engineered Cardiac Constructs. Critical Review in Biomedical Engineering. (In press, 2016)

2. William Zhang, Salma Ayoub, Jun Liao, Michael S. Sacks. A Meso-scale Layer-Specific Structural Constitutive Model of the Mitral Heart Valve Leaflets. Acta Biomaterialia. 32: 238–255, 2016

3. Rupak Dua,  Kristin Comella,  J. Ryan Butler,  Glenda Castellanos,  Bryn Brazille,  Andrew Claude,  Arvind Agarwal,  Jun Liao,  Sharan Ramaswamy. Integration of Stem Cell to Chondrocyte-Derived Cartilage Matrix in Healthy and Osteoarthritic States in the Presence of Hydroxyapatite Nanoparticles. PLOS ONE. DOI:10.1371/journal.pone.0149121, 2016

4. Amanda Pinheiro, Avery J. Cooley, Jun Liao, Raj Prabhu, and Steve Elder. Comparison of Natural Crosslinking Agents for the Stabilization of Xenogenic Cartilage. Journal of Orthopaedic Research. DOI:10.1002/jor.23121, 2016

5. Erin Brinkman, Sourav Patnaik, Benjamin Weed, Bryn Brazile, Robert Wills, Nicholas Olivier, Dodd Sledge, Avery J. Cooley, Jun Liao, Ann Rashmir. Cardiac findings in horses with heritable equine regional dermal asthenia. Journal of the American Veterinary Medical Association. (In  press, 2016)

2015
6. Bryn Brazile, Bo Wang, Guangjun Wang, Robbin Bertucci, Raj Prabhu, Sourav Patnaik, J. Ryan Butler, Andrew Claude, Erin Brinkman-Ferguson, Lakiesha N. Williams, and Jun Liao. On the Bending Properties of Porcine Mitral, Tricuspid, Aortic, and Pulmonary Valve Leaflets. Journal of Long-Term Effects of Medical Implants. 25:1-14, 2015

7. Wuwei Li, Guowu Ma, Bryn Brazile, Nan Li, Wei Dai, J Ryan Butler, Andrew A Claude, Jason A Wertheim, Jun Liao, Bo Wang. Investigating the Potential of Amnion-Based Scaffolds as a Barrier Membrane for Guided Bone Regeneration. Langmuir. 31 (31): 8642-8653, 2015

8. John Clemmer, Raj Prabhu, Joseph Chen, Erin Colebeck, Lauren B Priddy, Michael McCollum, Bryn Brazile, Wilbur Whittington, Jennifer L Wardlaw, Hongjoo Rhee, M F Horstemeyer, Lakiesha N. Williams, Jun Liao. Experimental Observation of High Starin Rate Responses of Porcine Brain, Liver, and Tendon. Journal of Mechanics in Medicine and Biology, 1650032, 2015

9. Benjamin Weed, Sourav Patnaik, Mary Rougeau-Browning, Bryn Brazile, Jun Liao, Raj Prabhu, Lakiesha N. Williams. Experimental Evidence of Mechanical Isotropy in Porcine Lung Parenchyma. Materials. 8 (5): 2454-2466, 2015

10. Raj Prabhu, W. R. Whittington, Sourav S. Patnaik, Y. Mao, Mark. T. Begonia, Lakiesha. N. Williams, Jun Liao, Mark F. Horstemeyer. A Coupled Experiment-Finite Element Modeling Methodology for Assessing High Strain Rate Mechanical Response of Soft Biomaterials. Journal of Visualized Experiments. 25(1–2): 41–53, 2015

11. Ali Azadi, Sourav S Patnaik, Jacek B Jasinski, Sean L Francis, Zhenmin Lei, Jun Liao, Nicolette E Deveneau, Donald R Ostergard. Morphologic Evaluation of Post-implanted Monofilament Polypropylene Mesh Utilizing a Novel Technique with Scanning Electron Microscopy Quantification. Surgical technology international. 26: 169-173, 2015

12. Chung-Hao Lee, Will Zhang, Jun Liao, Christopher A. Carruthers, Jacob I. Sacks, Michael S. Sacks. On the Presence of Affine Fibril and Fiber Kinematics in the Mitral Valve Anterior Leaflet. Biophysical journal. 108 (8), 2074-2087, 2015

13. Leslie N. Sierad, Eliza L. Shaw, Alexander Bina, Bryn Brazile, Nicholas Rierson, Sourav S. Patnaik, Agneta Simionescu, Jun Liao, Ionela Movileanu, Marius Harpa, Dan T. Simionescu. Functional Heart Valve Scaffolds Obtained by Complete Decellularization of Porcine Aortic Roots in a Novel Differential Pressure Gradient Perfusion System. Tissue Eng Part C Methods. (Epub ahead of print, PMID: 26467108), 2015

14. Feize Li, Jijun Yang, Jiali Liao, Shoujian Li, Jun Liao, Raj Prabhu, Lakiesha N Williams, Yuanyou Yang, Jun Tang, Ning Liu. Direct synthesis of carbon-based microtubes by hydrothermal carbonization of microorganism cells. Chemical Engineering Journal. 276: 322-330, 2015

15. Sourav S Patnaik, Bryn Brazile, Vani Dandolu, Peter L Ryan, Jun Liao. Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome: A historical perspective. Gene. Jan 15;555(1):33-40, 2015

2014
16. Renee Pietsch, Benjamin B. Wheatley, Tammy L. Haut Donahue, Ryan Gilbrech, Raj Prabhu, Jun Liao, Lakiesha N William. The Anisotropic Compressive Properties of Porcine Muscle Tissue. Journal of Biomechanical Engineering. 136(11), 111003, 2014

17. Mark Begonia, Ruiyi Wu, Rajkumar Prabhu, Jun Liao, Wilburn R. Whittington, Andrew Claude, Bridget Willeford, Jennifer Wardlawe, Song Zhang, Lakiesha Williams. Quantitative Analysis of Rodent Brain Microstructure Following Mild Blunt and Blast Trauma. Journal of Biomechanics. 47:3704-3711, 2014

18. Yanyi Xu, Sourav Patnaik, Xiaolei Guo, Zhenqing Li, Wilson Lo, Ryan Butler, Andrew Claude, Zhenguo Liu, Ge Zhang, Jun Liao, Peter M Anderson, Jianjun Guan. Cardiac Differentiation of Cardiosphere-Derived Cells in Scaffolds Mimicking Morphology of the Cardiac Extracellular Matrix. Acta Biomaterialia. Aug;10(8):3449-62, 2014

19. Benjamin C. Weed, Toree L. Bova, Sourav S. Patnaik, Bryn Brazile, Cate Mochal-King, Bryan Rude, R. Prabhu, Lakiesha N. Williams, Jun Liao. 3D Printing–Assisted Rapid Prototyping and Optimization: Development of a Novel Small Intestinal Cannula for Equine Research. 3D Printing and Additive Manufacturing 1 (2), 104-106, 2014

20. Nayeon Lee, M. F. Horstemeyer, Hongjoo Rhee, Ben Nabors, Jun Liao, Lakiesha N. Williams. Hierarchical multiscale structure–property relationships of the red-bellied woodpecker (Melanerpes carolinus) beak. Journal of The Royal Society Interface 11 (96), 20140274, 2014

21. Alan D. Freed, Jun Liao, Daniel R. Einstein. A Membrane Model from Implicit Elasticity Theory: Application to Visceral Pleura. Biomechanics and Modeling in Mechanobiology. 13(4): 871-881, 2014

22. Kyle Johnson, Wes Trim, M. F. Horstemeyer, Nayeon Lee, Lakiesha Williams, Jun Liao, Hongjoo Rhee and R Prabhu. Geometric effects on stress wave propagation. Journal of Biomechanical Engineering. 136 (2), 021023, 2014

23. Valtresa Myles, Jun Liao, James N. Warnock. Cyclic Pressure and Angiotensin II Influence the Biomechanical Properties of Aortic Valves. Journal of Biomechanical Engineering. 136(1):011011, 2014

2013
24. Bo Wang, Guangjun Wang, Filip To, J. Ryan Butler, Andrew Claude, Ronald M. McLaughlin, Lakiesha N. Williams, Amy L. de Jongh Curry, and Jun Liao. “Myocardial Scaffold-based Cardiac Tissue Engineering: Application of Coordinated Mechanical and Electrical Stimulations.” Langmuir. 29(35): 11109-17, 2013

25. Jeremy Mercuri, Sourav S Patnaik, Grace Dion, Sanjitpal Gill, Jun Liao, and Dan T. Simionescu. “Regenerative Potential of Decellularized Porcine Nucleus Pulposus Hydrogel Scaffolds; Stem cell Differentiation, Matrix Remodeling and Biocompatibility Studies.” Tissue Engineering Part A. Apr;19(7-8):952-66, 2013

26. James P. Chow, Dan T. Simionescu, Harleigh Warner, Bo Wang, Sourav S. Patnaik, Jun Liao, Agneta Simionescu, “Mitigation of diabetes-related complications in implanted collagen and elastin scaffolds using matrix-binding polyphenol.” Biomaterials, Jan;34(3):685-95, 2013

2012
27. Richard L. Summers, Weston Smith, Jun Liao Ryan Gilbrech, Benjamin C. Weed, Sourav Patnaik, and, “Influence Of Microgravity On Left Ventricular Sphericity: A Finite Element Model Of The Heart.” The American Institute of Aeronautics and Astronautics (AIAA) Journal, 2012

28. Bo Wang, Mary E. Tedder, Clara E. Perez, Guangjun Wang, Amy L. de Jongh Curry, Filip To, Steve H. Elder, Lakiesha N. Williams, Dan T. Simionescu, and Jun Liao. “Structural and Biomechanical Characterizations of Porcine Myocardial Extracellular Matrix.” Journal of Materials Science – Materials in Medicine, Aug;23(8):1835-47, 2012

29. Benjamin C. Weed, Ali Borazjani, Sourav S. Patnaik, Rajkumar Prabhu, Mark F. Horstemeyer, Peter L. Ryan, Thomas Franz, Lakiesha N. Williams, Jun Liao. “Stress State and Strain Rate Dependence of the Human Placenta.” Annals of Biomedical Engineering, Oct;40(10):2255-65, 2012

30. Dan T. Simionescu, Joseph Chen, Michael Jaeggli, Bo Wang, Jun Liao. “Form Follows Function: Advances in Trilayered Structure Replication for Aortic Heart Valve Tissue Engineering.” Journal of Healthcare Engineering, 3(2): 179–202, 2012

31. Jun Liao, Erinn M. Joyce, W. David Merryman, Hugh L. Jones, Mina Tahai, Mark F. Horstemeyer, Lakiesha N. Williams, Richard A. Hopkins, and Michael S. Sacks. “The Intrinsic Fatigue Mechanism of Porcine Aortic Valve Extracellular Matrix.” Cardiovascular Engineering and Technology, 3(1):  62-72, 2012

2011
32. Jianjun Guan, Feng Wang, Zhenqing Li, Joseph Chen, Xiaolei Guo, Jun Liao, Nicanor I. Moldovan. “The Stimulation of the Cardiac Differentiation of Mesenchymal Stem Cells in Tissue Constructs that Mimic Myocardium Structure and Biomechanics.” Biomaterials, 32(24):5568-80, 2011

33. R. Prabhu, M.F. Horstemeyer, M. Tucker, E.B. Marin, J.L. Bouvard, J. Sherburn, Jun Liao, Lakiesha Williams. “Coupled Experiment/Finite Element Analysis on the Mechanical Response of Porcine Brain under High Strain Rates” Journal of the Mechanical Behavior of Biomedical Materials, 4(7):1067-80, 2011

34. Ali Borazjani, Benjamin Weed, Sourav Patnaik, Jean Feugang, David Christiansen, Steven H. Elder, Peter L. Ryan, and Jun Liao. “A Comparative Biomechanical Analysis of Term Fetal Membranes in Human and Domestic Species.” American Journal of Obstetrics and Gynecology, 204(4):365.e25-36, 2011

35. K. Jane Grande-Allen and Jun Liao. “The Heterogeneous Biomechanics and Mechanobiology of the Mitral Valve: Implications for Tissue Engineering.” Current Cardiology Reports, 13(2):113-20, 2011

36. Mary E. Tedder, Agneta Simionescu, Joseph Chen, Jun Liao, Dan T. Simionescu. “Assembly and testing of stem cell-seeded layered collagen constructs for heart valve tissue engineering.” TISSU ENGINEERING Part A, 17(1-2):25-36, 2011

37. Wes Trim, Mark F. Horstemeyer, Hongjoo Rhee, Seong-Jin Park, Haitham El Kadiri, Lakiesha Williams, Jun Liao, and Joanna McKittrick. “Parametric study of the structure-property relations of bighorn sheep (Ovis canadensis) horn” Acta Biomaterialia, 7(3):1228-40, 2011

38. Emanuel Villa, Alayne Stewart White, Jun Liao, and Amy L. de Jongh Curry. "An Inexpensive Alternative Bath System for Electrophysiological Characterization of Isolated Cardiac Tissue." IEEE Eng Med Biol Soc: page: 8424-7, 2011

2010
39. John Clemmer, Jun Liao, Debbie Davis, Mark F. Horstemeyer, and Lakiesha Williams. “A Mechanistic Study for Strain Rate Sensitivity of Rabbit Patellar Tendon.” JOURNAL OF BIOMECHANICS, 43(14):2785-91, 2010

40. Leslie N Sierad, Agneta Simionescu, Joseph Chen, Christopher Albers, Jordan Maivelett, Mary E Tedder, Jun Liao, Dan T. Simionescu. “Design and testing of a pulsatile conditioning system for dynamic endothelialization of polyphenol-stabilized tissue engineered heart valves.” Cardiovascular Engineering and Technology, Vol. 1 (2): 138–153, 2010

41. Bo Wang, Ali Borazjani, Mina Tahai, Amy L. de Jongh Curry, Dan T. Simionescu, Jianjun Guan, Filip To, Steve H. Elder, and Jun Liao. “Fabrication of Cardiac Patch with Decellularized Porcine Myocardial Scaffold and Bone Marrow Mononuclear Cells.” JOURNAL OF BIOMEDICAL MATERIALS RESEARCH Part A, 15;94(4):1100-10, 2010

42. Mark T. Begonia, Raj Prabhu, Jun Liao, Mark F. Horstemeyer Lakiesha N. Williams. “The influence of strain rate dependency on the structure-property relations of porcine brain.” ANNALS OF BIOMEDICAL ENGINEERING, 38(10):3043-57, 2010

43. Song Zhang, J. Allen Crow, Xiaoyong Yang, Joseph Chen, Ali Borazjani, Katie B Mullins, Wei Chen, Robert C. Cooper, Ronald M. McLaughlin, Jun Liao. “The Correlation of 3D DT-MRI Fiber Disruption with Structural and Mechanical Degeneration in Porcine Myocardium.” ANNALS OF BIOMEDICAL ENGINEERING, 38(10):3084-95, 2010

44. James Warnock, Carol Pregonero Gamez, Scott Metzler, Joseph Chen, Steven Elder, and Jun Liao. Vasoactive Agents Alter the biomechanical Properties of Aortic Heart Valve Learlets in a Time-dependent Manner, JOURNAL OF HEART VALVE DISEASE, 19(1): 86-96, 2010

2009
45. Wei Chen, Zhicheng Yan, Song Zhang, John A. Crow, Ronald M. McLaughlin, Katie B. Mullins, Robert Cooper, David Ebert, Zi’ang Ding, and Jun Liao,. Modeling and Illustration of Muscle from Diffusion Tensor Images. IEEE Transactions on Visualization and Computer Graphics, 15(6):1425-32, 2009

46. Jun Liao, Lauren B. Priddy, Bo Wang, Joseph Chen, and Ivan Vesely. “Ultrastructure of Porcine Mitral Valve Chordae Tendineae.” JOURNAL OF HEART  VALVE DISEASE, 18(3), 292-299, 2009

47. Erin M. Joyce, Jun Liao, John E. Mayer, Michael S. Sacks. Effects of Transvalvular Pressure on Pulmonary Valve Microstructure, ANNALS OF THORACIC SURGERY. 87(4):1240-9, 2009

48. Corin Williams, Jun Liao, Erinn M. Joyce, Bo Wang, Jennie B. Leach, Michael S. Sacks, and Joyce Y. Wong. “Structural and Mechanical Properties of Decellularized Rabbit Carotid Arteries.” ACTA BIOMATERIALIA, 5(4):993-1005, 2009

49. Mary E. Tedder, Jun Liao, Benjamin Weed, Christopher Stabler, Henry Zhang, Agneta Siminonescu, and Dan T. Siminonescu. “Stabilized acellular pericardium: novel collagen scaffold for heart valve tissue engineering.” TISSU ENGINEERING Part A, 15(6):1257-68, 2009

2008
50. Jun Liao, Erin M. Joyce, Michael S. Sacks. Effects of decellularization on mechanical and structural properties of the porcine aortic valve leaflets, BIOMATERIALS. Mar; 29(8):1065-74, 2008.

51. John A. Stella, Jun Liao, Yi Hong, W. David Merryman, William R. Wagner, and Michael S. Sacks. Tissue-Cellular Deformation Coupling in Cell-Micro integrated Electrometric Scaffolds. BIOMATERIALS. 29(22):3228-36, 2008

52. Pietro Bajona, Kenton J. Zehr, Jun Liao, Giovanni Speziali. “Tension Measurement of Artificial Chordae Tendineae Implanted Between the Anterior Mitral Valve Leaflet and the Left Ventricular Apex: An In Vitro Study.” INNOVATIONS: Technology and Techniques in Cardiothoracic and Vascular Surgery. Vol. 3 (1) 33-37, 2008

2007
53. Jun Liao, Lin Yang, Jonathan S. Grashow, Michael S. Sacks. "The relation between collagen fibril kinematics and mechanical properties in the mitral valve anterior leaflet," JOURNAL OF BIOMECHANICAL ENGINEERING, Feb; 129 (1):78-87, 2007

54. Jun Liao, Ivan Vesely. "Skewness Angle of Interfibrillar Proteoglycans Increases with Applied Load on Chordae Tendineae." JOURNAL OF BIOMECHANICS, 40(2):390-8, 2007

55. John A. Stella, Jun Liao, and Michael S. Sacks. "Time dependent biaxial mechanical behavior of the aortic heart valve leaflet." JOURNAL OF BIOMECHANICS, 40(14):3169-77, 2007
56. W. David Merryman, Jun Liao, Aeron Parekh, Joseph E. Candiello, Hai Lin, Michael S. Sacks. "The Heart Valve Interstitial Cell Cytoskeleton: Role in Cell Stiffness, Contraction and Tissue Remodeling," TISSUE ENGINEERING 13 (9): 2281-2289 SEP 2007

57. H.Y. Shadow Huang, Jun Liao, and Michael S. Sacks. "In-situ deformation of the aortic heart valve interstitial cell nucleus under diastolic loading." JOURNAL OF BIOMECHANICAL ENGINEERING 129(6):880, 2007

2003-2006
58. Jonathan S. Grashow, Michael S. Sacks, Jun Liao, Ajit P. Yoganathan. "Planar biaxial creep and stress relaxation of the mitral valve anterior leaflets." ANNALS OF BIOMEDICAL ENGINEERING Oct; 34 (10): 1509-18, 2006

59. W. David Merryman, George C. Engelmayr, Jun Liao, and Michael S. Sacks. "Defining Biomechanical Endpoints for Tissue Engineered Heart Valve Leaflets from Native Leaflet Properties." PROGRESS IN PEDIATRIC CARDIOLOGY Vol. 21, pp. 153-60, 2006

60. Jun Liao, Lin Yang, Jonathan S. Grashow, Michael S. Sacks. "Molecular orientation of collagen in intact planar connective tissue under biaxial stretch." ACTA BIOMATERIALIA, Vol. 1, p. 45-54, 2005

61. Jun Liao, Ivan Vesely. "The relationship between collagen fibrils, glycosaminoglycans and stress relaxation in mitral valve chordae tendineae." ANNALS OF BIOMEDICAL ENGINEERING Jul;32(7):977-83, 2004

62. Jun Liao, Ivan Vesely. "A structural basis for the size-related mechanical properties of mitral valve chordae tendineae." JOURNAL OF BIOMECHANICS 36/8: p1125-1133, 2003

1999-2000
63. Liao J, Jiang XP, Xu GS, et al. Investigation of the effect of the annealing process on the domain structure of 0.65Pb(Mg1/3Nb2/3)O-3-0.35 PbTio(3) single crystal using scanning electron acoustic microscopy. MATERIAL CHARACT 44: (4-5) 453-457 APR-MAY 2000

64. Liao J, Yang Y, Jiang XP, et al. Scanning electron acoustic imaging of residual stress distributions in ceramic coatings and sintered ceramics. MATERIAL LETTER 39: (6) 335-338 JUN 1999

65. Liao J, Yang Y, Hui SX, et al. Observation of domain movement on BaTiO3 crystal under applied electric filed by scanning electron acoustic microscope. FERROELECTRICS 231: (1-4) 643-648 1999

66. Liao J, Jiang XP, Hui SX, et al. The study of domain rearrangement under external electric fields by scanning electron acoustic microscope. FERROELECTRICS LETTER 26: (3-4) 53-59 1999

BOOK CHAPTERS
1. Sourav S. Patnaik, Ali Borazjani, Bryn Brazile, Benjamin Weed, David Christiansen, Peter L. Ryan, C.H. van der Vaart, Margot Damaser, Jun Liao. Chapter: "Pelvic Floor Biomechanics from Animal Models" in Biomechanics of the Female Pelvic Floor, Editors: Hoyte and Margot Damaser, Elsevier, (in press, 2016)

2. Bo Wang, Lakiesha Williams, Amy L. de Jongh Curry, Jun Liao. Chapter Title: “Preparation of Acellular Myocardial Scaffolds with Well-preserved Cardiomyocyte Lacunae, and Method for Applying Mechanical and Electrical Simulation to Tissue Construct.” Book Title: Cardiac Tissue Engineering Methods and Protocols. Editors: Milica Radisic and Lauren Black; Springer Science. 1181:189-202, 2014

3. Sourav S. Patnaik, Bo Wang, Benjamin Weed, Jason A. Wertheim, Jun Liao, Chapter 3: “Decellularized Scaffolds: Concepts, Methodologies, and Applications in Cardiac Tissue Engineering and Whole-Organ Regeneration,” Tissue Regeneration: Where Nanostructure Meets Biology, Editor: Qing Liu; World Scientific Company, page 77-124, 2013

4. Dan T. Simionescu, Joseph Chen, Michael Jaeggli, Bo Wang, Jun Liao. Chapter Title: “Form Follows Function: Advances in Trilayered Structure Replication for Aortic Heart Valve Tissue Engineering. Book Title: “Advances in Engineering for Surgery – from information-guided surgery to cell-based medicine.” Editor: Ming Chyu; Multi-Science Publishing Company; Page 25-248, 2013

5. John A. Stella, Jun Liao, Yi Hong, W. David Merryman, William R. Wagner, and Michael S. Sacks. "Tissue-to-cellular deformation coupling in cell microintegrated elastomeric scaffolds." IUTAM Symposium on Cellular, Molecular and Tissue Mechanics, IUTAM Bookseries: Volume 16 (Part 2) 81-89, Springer Netherlands, 2010.